Fetus is a reference to Super Meat Boy and the Dramatic Chipmunk meme. The fifth ending where Isaac finds Dr.The sound effect that can be heard as Isaac flashes through his different incarnations in the Sheol ending is the same as the sound effect used in McMillen's game Time Fcuk when switching to a different layer.The "Get in the box!" message from The Chest ending is a reference to Time Fcuk, another game by Edmund McMillen.GET IN THE BOX! A reference from Time Fcuk. Each one shows Isaac unlocking a large Golden Chest, who promptly finds an Item, with the exception of the first, sixth and tenth endings. Upon defeating Mom, The Womb is unlocked, with the final boss being Mom's Heart/ It Lives!. The door crashes open and his mother is in the doorway, brandishing her large kitchen knife, then the video fades to the credit sequence. The video then switches to a different perspective and style where Isaac has just put up his latest drawing on the wall. The narration references an angel intervening on God's behalf at the last moment, which is how Abraham's hand was stayed in the Biblical story as well.
Isaac's mother corners him and is about to sacrifice him, when the Bible falls off a shelf above her, hitting her and knocking her out. It is in the same style as the intro and drawn by Isaac himself. In the epilogue, the story of The Binding of Isaac at first appears to come to a close that parallels its Biblical source. This ending is seen upon defeating Mom in The Depths 2.
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